The Red Volta River and the forest reserves bordering it serve as the main corridor for the movement of wildlife, particularly elephants, between Ghana and Burkina Faso. Unfortunately, because these forest reserves are degraded, they are unable to support the herds of elephants that lately come out of the reserve and raid the farms of the fringe communities leading to human-elephant conflicts and the killing of the elephants. This study assessed the population size and distribution of the elephants along the river in particular and the Northeastern corner of Ghana in general. It also mapped out the high risk areas for better management of the crop-raiding problem. The study elucidated the factors that lead to human-elephant conflicts and proposed a management strategy for reducing elephant crop-raiding in the Red Volta River area.